Does Changing Page/Post URL and Location Negatively Affect Anything?

I've had a website on the back burner for a while. I made it over a year ago, and there has always been one page that no matter what I do to it's on-page seo, it wont rank in the top 200 for its targeted keyword (competition is low-med).

The only unique thing about this page is I had moved it (a 3,000 word article) from being an inner page on my website (after it was indexed), to setting it as the homepage. And ever since then it (now my homepage) will never seem to rank for its keyword in…

Does Changing Page/Post URL and Location Negatively Affect Anything?